Tag Archives: Fiasp

Fun with Fiasp.

As I mentioned in my previous post on this subject, my endocrinologist provided me with a sample vial of Fiasp so I could try it out in my insulin pump. This is only my opinion… before starting or stopping a medication, especially insulin, check with your doctor.

For anyone who hasn’t heard of it yet, Fiasp is Novo Nordisk’s faster acting insulin– in fact, Fiasp stands for Faster-acting Insulin ASPart. It was approved by the U.S. Food and Drug Administration last September. I was able to try it out in my pump for about a week.

When I did an informal poll of this new insulin via Facebook, I got a series of answers. Some people love it, some hate it, some made adjustments, some went running back to their previous insulin. I really didn’t have an idea of what to expect before beginning my trial.

But I did think of some of the experiences shared on that thread when considering my own experience with Fiasp.

To begin with, let’s talk about the faster acting part of the equation. Maybe I’m a little more sensitive than I thought, but the first two or three boluses really hit me hard. Even if it took a little more time to kick in, when it hit me, my blood sugar would plummet.

The science behind this is a combination of Vitamin B3 and an amino acid known as L-Arginine. The first is to speed up the insulin’s absorption time, and the other is to help maintain the insulin’s stability.

After the first couple of boluses though, there didn’t seem to be any more of an impact with Fiasp than there was with the Novolog I’ve used up to now. The only difference I could notice was with pre-bolusing. I like to pre-bolus for a meal, but like anyone else, I’m not always perfect… sometimes I forget.

When that happened, the Fiasp allowed for some forgiveness of forgetfulness, allowing me to bolus late without any measurable post-meal BG spikes.

A couple of people mentioned feeling a burning sensation when injecting Fiasp. I didn’t really experience that. For me, it was more of a feeling like the insulin was thicker somehow, like something oversize was trying to squeeze its way past the tiny constraints of the cannula and under my skin.

Both times I changed out infusion sites while using Fiasp, I found blood about a foot up inside the tubing of my set. I don’t know if this phenomenon had anything to do with it, but blood in the tubing is a very rare occurrence for me.

It should also be noted that I’m using the now defunct Animas Vibe pump, which dispenses insulin at a rapid rate. If I had been using, say, a t:slim pump, which delivers insulin at a glacial pace, the result might have been different. You never know.

As far as in-range or out-of-range blood sugars go, there wasn’t really much difference between Fiasp and the Novolog I use on a regular basis. I had one post-workout BG in the upper 200s (mg/dL), which is not common for me. Otherwise, my highest highs were around 200.

Looking at the entire experience of my time on Fiasp, I can say that there just wasn’t much difference other than what’s noted above. In the end, yeah, there were differences… but not so much of a benefit using Fiasp that it’s going to make me want to go away from Novolog. Especially since Novo Nordisk products are not on my prescription provider’s formulary anyway.

If my out of pocket cost was less than what I’m shelling out now, I might make the switch. Same price? I’ll stick with what I have.

Again, this is just my experience using this drug. I’m not a medical expert. I also encourage you to learn more about Fiasp, by reading THIS from Diabetes Mine and THIS from diaTribe.

You can get additional first person accounts of Fiasp by reading about Julia’s experience HERE and Anna’s experience HERE.

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My turn.

I went for my quarterly visit with my endocrinologist last week. We talked about a great many things.

My A1c is still excellent, but she’s concerned about night time lows. We lowered my overnight basal rate, and that seems to have solved my problem for now.

But I’ve been concerned about the amount of insulin I’m injecting these days. Along with the overnight lows, I’m seeing more numbers over 200 mg/dL than I’m used to.

For the first time in the eight years I’ve been seeing her, we used the words “insulin resistance”. As in, I feel it’s taking a lot more insulin to bring me within range than it used to. I’m very concerned about that, especially because extra insulin not used means extra insulin stored as fat around my midsection. I have enough of that already.

We talked about the fact that I’m active, but also in my mid-50s, which means my metabolism is crap. I eat less now than I probably have at any time as an adult, but I’m frustrated that I can’t seem to drop the weight in measurable numbers.

For now, the plan is to let my endo manage my basal rates, and I will handle the boluses, possibly including dropping my insulin to carb ratio. The change in basals is keeping me from going low overnight. I haven’t lowered the I:C ratio yet, but I’m thinking about it. Those post-meal spikes are really bothering me.

At the end of the visit, she asked if I was considering another pump to replace my Animas Vibe (Animas is out of business in the USA). I told her my general feelings about the various pump options out there today.

I also told her if those options don’t change by the time my warranty is up, I may consider going back to multiple daily injections. After all, a faster-acting insulin is available now, and maybe that will make a difference. She excused herself for a moment, and came back with this:

A sample vial of Novo Nordisk’s Fiasp, the faster-acting insulin we were talking about. I was under the impression that it could only be injected via a syringe. I don’t do that often, but I told her if I ever needed a correction bolus or my pump failed, I would give it a try.

She encouraged me to try it with my pump. I took the sample home, and then took to Facebook to see if there was anyone else who had used Fiasp in a pump.

If you ever want opinions, just ask what People With Diabetes think about a product, and you will get all kinds of responses. I certainly did. Some people love Fiasp. Some hate it. Some see it as very effective in their pump for a day or two, and then not effective at all after that. Some have no desire to try it at all.

I was glad to get all of that feedback. In the end, the decision will be up to me to decide how I like this new insulin. For a little while though, it’s my turn to try it out in my insulin pump. More to come on this in a couple of weeks.

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